The best time to visit Rome, Florence, and Venice is during the spring (April to June) or autumn (September to October). These months offer pleasant weather, fewer crowds, and vibrant cityscapes. Summer (July and August) can be very hot, especially in Rome and Florence, while Venice experiences higher humidity. Winter (November to February) is quieter and ideal for travelers looking to explore without the tourist rush. 

A well-planned Rome Florence Venice itinerary typically takes 7 to 10 days. Spend 3 days in Rome to explore its ancient landmarks, 2 to 3 days in Florence for Renaissance art and Tuscan charm, and 2 to 3 days in Venice to enjoy its canals and unique architecture. This allows ample time to immerse yourself in the highlights of each city. 

The easiest way to travel between these cities is by high-speed train. The train journey from Rome to Florence takes about 1.5 hours, and Florence to Venice takes about 2 hours. Trains are fast, comfortable, and allow you to enjoy scenic views. Alternatively, you can also travel by car or book guided tours for your Rome Florence Venice itinerary. 

Pack comfortable walking shoes, as these cities involve a lot of exploring on foot. Light clothing is suitable for summer, while layers and waterproofs are recommended for cooler months. Don’t forget essentials like sunglasses, sunscreen, and a travel adapter. For Venice, consider waterproof shoes if visiting during the acqua alta (high tide) season.